Research & Development

Validation of the Innogenetics MBL genotyping kit
Mannose-binding lectin (MBL) is an important host defence protein against many pathogens. So far, research into the effects of MBL on fungal infections has been very limited; however, recent reports indicate the need for further studies.
This project aims to compare MBL genotype to levels of MBL as measured in the serum. Patients attending the infectious diseases clinic suffering from chronic pulmonary aspergillosis (CPA) or allergic bronchopulmonary aspergillosis (ABPA) were tested. Two blood samples were collected. One specimen was sent for measurement of serum MBL concentrations, using an ELISA procedure. The other was analysed for MBL genotype, performed using the INNO-LiPA MBL2 kit. Statistical analyses were then performed to determine any link between functional and non-functional genotypes, and serum levels.