Research & Development - Current projects
Taxonomy of Aspergillus flavus complex
The phylogeny of clinical Aspergillus isolates belonging to the section flavi was studied by sequencing three genes sequences; O –methyltransferase, beta-tubulin, and the ITS Region and by comparing morphology and susceptibility profiles with known reference strains. (more details)
Validation of the Innogenetics MBL genotyping kit
This project aimed to compare MBL genotype to levels of MBL as measured in the serum, in patients suffering from chronic pulmonary aspergillosis (CPA) or allergic bronchopulmonary aspergillosis (ABPA). This will determine any link between functional and non-functional genotypes, and serum levels. (more details)
Understanding resistance mechanisms in azole resistant Aspergillus fumigatus
This study designed to investigate the frequency of azole resistance in Aspergillus fumigatus in the RMLM culture collection. Resistant isolates were studied to determine their susceptibility profiles (cross-resistance pattern), the mechanism of resistance, and their genetic relatedness by molecular typing. (more details)
Taxonomy of Aspergillus niger complex
The taxonomy of black sporing Aspergilli in the RMLM culture collection was studied by sequencing of 3 molecular targets; ITS region, and partial calmodulin and beta-tubulin genes. (more details)
Relationship of itraconazole levels to toxicity (audit)
This project was set to audit the relationship between itraconazole (ITZ) concentrations and the probability of toxicity. The relationship between mean ITZ concentrations and the probability of an adverse event was defined using logistic regression. (more details)
Relationship of itraconazole levels to toxicity (audit)
This project was set to audit the relationship between itraconazole (ITZ) concentrations and the probability of toxicity. The relationship between mean ITZ concentrations and the probability of an adverse event was defined using logistic regression. (more details)
The nature of individual isolates in aspergillomas
This project aimed to analyse surgically-resected aspergillomas in several ways, including the differences between and evolution of the isolates obtained, their antifungal susceptibility patterns, gene expression and rearrangement profiles and mycotoxin production. (more details)
View Publications 1993-2008 arising from studies carried out in the Mycology Centre
Recent Posters
Harrison E, Pasqualotto A, Howard S, Anderson M, Denning D, Bowyer P. Microevolution of Aspergillus fumigatus in Aspergillomas. 9th European Conference on Fungal Genetics, Edinburgh, UK. April 2008.
Moore CB, Duddy NE, Denning, DW, Hope WW. Development of a bioassay for posaconazole blood levels and its use in the clinical laboratory. 18th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain. April 2008.
Gray VL, Duddy NE, Harris S, Howard SJ, Denning DW, Moore CB. In vitro susceptibility of Candida species to micafungin: a comparison of methods. 18th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain. April 2008.
Howard SJ, Harrison E, Bowyer P, Denning DW. Molecular identification of clinical black Aspergillus isolates and azole resistance. 3rd Advances Against Aspergillosis (AAA), Miami, USA. January 2008.
Harrison E, Howard SJ, Anderson M, Denning D, Bowyer P. Evolution of Aspergillus fumigatus in Aspergillomas. 3rd AAA, Miami, USA. January 2008.
Howard SJ, Albarrag A, Anderson MJ, Gardiner RE, Park S, Perlin D, Denning DW. Azole resistance in clinical Aspergillus fumigatus strains. 46th ICAAC, San Francisco, USA. October 2006.
Pasqualotto AC, Howard SJ, Moore CB, Denning DW. Flucytosine (5-FC) Levels: 15-years experience from the United Kingdom. 46th ICAAC, San Francisco, USA. October 2006.
Steel NE, Howard SJ, Moore CB, Warn P, Denning DW. Susceptibility of allergenic fungi to azoles. 16th Congress of the International Society for Human and Animal Mycology, Paris, France. June 2006.
Howard SJ, Moore CB, Denning DW. Azole resistance in Aspergillus niger. 2nd AAA, Athens, Greece. February 2006.